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TRIAL REFERENCES 500 - 599

500

Afferent signals regulating food intake. - Proc Nutr Soc. 2000 Aug;59(3):373 – 84 - Bray GA - Pennington Biomedical Research Center, Louisiana State University, 70808, USA. PubMed 10997653.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=10997653

501

Effects of hypocaloric diet low in essential fatty acids on in vitro human adipose tissue prostaglandin production and essential fatty acid status. - Nutrition. 1991 Jul – Aug;7(4):256 – 9. - Katz DP, Knittle JL. - Dept. of Anesthesiology, Montefiore Medical Center, Bronx, New York. PubMed 1802215.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=1802215

502

The biology of obesity. - Trayhurn P. - Neuroendocrine & Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, U.K. PubMed 15877920.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=15877920

503

Long-chain polyunsaturated fatty acids in plasma lipids of obese children. - Lipids. 1996 Mar;31(3):305 – 11 - Decsi T, Molnár D, Koletzko B. - Dept. of Paediatrics, University School of Pécs, Hungary. PubMed 8900460.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=8900460

504

Short-term diabetic ketosis alters n – 6 polyunsaturated fatty acid content in plasma phospholipids. - J Clin Endocrinol Metab Bassi et al. 81 (4): 1650. A Bassi, A Avogaro, C Crepaldi, P Pavan, S Zambon, R Marin, I Macdonald and E Manzato - University of Padova, Italy.
http://jcem.endojournals.org/cgi/reprint/81/4/1650

505

Metabolic control of sexual function and growth: role of neuropeptide Y and leptin. - Mol Cell Endocrinol. 1998 May 25;140(1 – 2):107 – 13 - Aubert ML, Pierroz DD, Gruaz NM, d’Alleves V, Vuagnat BA, Pralong FP, Blum WF, Sizonenko PC. - Dept. of Pediatrics, School of Medicine, Geneva, Switzerland. PubMed 9722177.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=9722177

506

Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats. - J Physiol. 2002 Nov 15;545(Pt 1):255 – 68 - Watanobe H. Division of Internal Medicine, International University of Health and Welfare, Tochigi, Japan. PubMed 12433965.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=12433965

507

Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear - factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase - Endocrinology. 2005 Aug;146(8):3334 – 42. Epub 2005 May 19 - Lappas M, Permezel M, Rice GE. - Dept. of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, East Melbourne, Victoria, Australia. PubMed 15905315.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=15905315

508

Long-term effects of diet on leptin, energy intake, and activity in a model of diet-induced obesity - J Appl Physiol 93: 887 – 893, 2002. - Christian K. Roberts, Joshua J. Berger, and R. James Barnard Dept. of Physiological Science, University of California, Los Angeles, California USA.
http://jap.physiology.org/cgi/content/full/93/3/887?ck=nck

509

Analysis of paradoxical observations on the association between leptin and insulin resistance - The FASEB Jnl. 2002;16:1163 –1176 - Rolando B. Ceddia, Heikki A. Konistinen, Juleen R. Zierath and Gary Sweeney - Dept. of Biology, York University, Toronto, Canada Integrative Physiology, Karolinska Institute, Stockholm, Sweden; and Dept. of Medicine, Division of Cardiology, Helsinki University Central Hospital, Finland.
http://www.fasebj.org/cgi/content/full/16/10/1163

510

Serum immunoreactive-leptin concentrations in normal-weight and obese humans. - N Engl J Med. 1996 Feb 1;334(5):292 – 5 - Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al.Division of Endocrinology, - Jefferson Medical College of Thomas Jefferson University, Philadelphia, USA. PubMed 8532024.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8532024

511

Leptin levels in rat offspring are modified by the ratio of linoleic to -linolenic acid in the maternal diet - Jnl. of Lipid Research, Vol. 43, 1743 – 1749, October 2002 - Marina Korotkova, Britt Gabrielsson, Malin Lönn, Lars-Åke Hanson and Brigitta Strandvik - Dept.s of Pediatrics, Dept. of Internal Medicine, Clinical Immunology, Dept. of Internal Medicine, Research Centre for Endocrinology and Metabolism, Dept. of Internal Medicine, Göteborg University,
http://www.jlr.org/cgi/content/abstract/43/10/1743

512

Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism - Am J Physiol Regul Integr Comp Physiol 288: R1682 – R1688, 2005 - Patricia Pérez-Matute, Amelia Marti, J. Alfredo Martínez, M. P. Fernández-Otero, Kimber L. Stanhope, Peter J. Havel, and María J. Moreno-Aliaga - Dept. of Physiology and Nutrition, University of Navarra, Pamplona, Spain; and Dept. of Nutrition, University of California, USA.
http://ajpregu.physiology.org/cgi/content/abstract/288/6/R1682

513

Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata). - Comp Biochem Physiol B Biochem Mol Biol. 2005 Dec;142(4): - Ganga R, Bell JG, Montero D, Robaina L, Caballero MJ, Izquierdo MS. - Grupo de Investigacion en Acuicultura. ULPGC & ICCM. Telde, Las Palmas, Canary Islands, PubMed 16257554.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16257554

514

Regulation of leptin release and lipolysis by PGE2 in rat adipose tissue. - Fain JN, Leffler CW, Bahouth SW, Rice AM, Rivkees - SA. Prostaglandins Other Lipid Mediat. 2000 Oct;62(4):343 – 50 - Dept. of Biochemistry, College of Medicine, University of Tennessee, Memphis, USA. PubMed 11060898.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=11060898

515

Arachidonic acid inhibits lipogenic gene expression in 3T3-L1 adipocytes through a prostanoid pathway - The Jnl. of Lipid Research, Vol. 39, 1327 – 1334, July 1998 - Michelle K. Mater, David Pan, W. G. Bergen, and Donald B. Jump - Dept.s of Physiology, Animal Science, Dept.s of Physiology, Botany and Plant Pathology, Dept.s of Physiology, Michigan State University, East Lansing, Michigan 48824 Dept. of Animal and Dairy Science, Auburn University, Auburn, AL 36849.
http://www.jlr.org/cgi/content/abstract/39/7/1327

516

Effects of Linoleic Acid (LA) and Conjugated Linoleic Acid (CLA) on Leptin - Patti Plett, H. Weiler, A. Angel - Dept. of Medicine and Nutritional Sciences, University of Manitoba, Winnipeg, MB
http://www.drtc.ca/plett.html.

517

Regulation of leptin release and lipolysis by PGE2 in rat adipose tissue. See 514.

518

Stimulation of leptin release by arachidonic acid and prostaglandin E(2) in adipose tissue from obese humans Metabolism. - 2001 Aug;50(8):921 – 8. - Fain JN, Leffler CW, Cowan GS, Buffington C, Pouncey L, Bahouth - SW. Dept. of Biochemistry, College of Medicine, University of Tennessee, Memphis, USA. PubMed 11474480
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=11474480.

519

Effects of supplemental rumen-protected conjugated linoleic acid or linoleic acid on feedlot performance, carcass quality, and leptin concentrations in beef cattle - J Anim Sci. 2004 Mar;82(3):851 – 9. - Gillis MH, Duckett SK, Sackmann JR, Realini CE, Keisler DH, Pringle TD. Dept. of Animal and Dairy Science, University of Georgia, USA. PubMed 15032443.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=15032443

520

Team Discovers a Chemical Pathway that Causes Mice to Overeat and Gain Weight.By Mark Schrope.
http://www.scripps.edu/newsandviews/e_20070226/eating.html

521

Dietary n – 3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter See 413.

522

Regulation of leptin secretion from white adipocytes by free fatty acids - Am J Physiol Endocrinol Metab 285: E521 – E526, 2003 - Philippe G. Cammisotto, Yves Gélinas, Yves Deshaies, and Ludwik J. Bukowiecki - Dept. of Anatomy and Physiology, Faculty of Medicine, Laval University, Quebec, Canada.
http://ajpendo.physiology.org/cgi/content/full/285/3/E521

523

Dietary n – 3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 (See 413).

524

Reduction of leptin gene expression by dietary polyunsaturated fatty acids. - J Lipid Res. 2001 May;42(5):743 – 50 - Reseland JE, Haugen F, Hollung K, Solvoll K, Halvorsen B, Brude IR, Nenseter MS, Christiansen EN, Drevon CA. - Institute for Nutrition Research, University of Oslo, P. O. Box 1046, Blindern, N – 0316 Oslo, Norway. PubMed 11352981.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=11352981

525

Increased uncoupling protein2 mRNA in white adipose tissue, See 431 above.

526

Chronic effects of different fatty acids and leptin in INS – 1 cells. - Diabetes Res Clin Pract. 2001 Jan;51(1):1 – 8 - Kawai T, Hirose H, Seto Y, Fujita H, Saruta T. - Dept. of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160 – 8582, Japan. PubMed 11137176.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=11137176

527

Regulation of leptin secretion from white adipocytes by free fatty acids. - Cammisotto PG, Gelinas Y, Deshaies Y, Bukowiecki LJ. - Dept. of Anatomy and Physiology, Faculty of Medicine, Laval University, Quebec, Canada.
http://ajpendo.physiology.org/cgi/content/full/285/3/E521

528

Eicosapentaenoic fatty acid increases leptin secretion from primary See 512 above.

529

Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity - George A Bray, Samara Joy Nielsen and Barry M Popkin - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA (GAB), and the Dept. of Nutrition, University of North Carolina, Chapel Hill (SJN and BMP).
http://www.ajcn.org/cgi/content/full/79/4/537

530

Consuming Fructose-sweetened Beverages Increases Body Adiposity in Mice Obesity - Research 13:1146 – 1156 (2005) - Hella Jürgens, Wiltrud Haass, Tamara R. Castañeda, Annette Schürmann, Corinna Koebnick, Frank Dombrowski, Bärbel Otto Andrea R. Nawrocki, Philipp E. Scherer, Jochen Spranger, Michael Ristow, Hans-Georg Joost, Peter J. Havel and Matthias H. Tschöp - German Institute of Human Nutrition, Dept. of Psychiatry, University of Cincinnati Otto-von-Guericke-University, Innenstadt University Hospital, Albert Einstein College of Medicine, Bronx, New Charité University Medicine, University of California Berlin,YorkMunich,Magdeburg.
http://www.obesityresearch.org/cgi/content/full/13/7/1146

531

Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity - American Jnl. of Clinical Nutrition, Vol. 79, No. 4, 537 – 543, April 2004 - George A Bray, Samara Joy Nielsen and Barry M Popkin - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA (GAB), and the Dept. of Nutrition, University of North Carolina, Chapel Hill.
http://www.ajcn.org/cgi/content/full/79/4/537

532

See 406.

533

The Weston A Price Foundation for Wise Traditions How To Restore Digestive Health By Jordan S. Rubin.
http://www.westonaprice.org/moderndiseases/restore_digestivehealth.html

534

Medium-Chain Triglycerides Increase Energy Expenditure and Decrease Adiposity in Overweight Men - Obesity Research 11:395 – 402 (2003) - Marie-Pierre St-Onge, Robert Ross, William D. Parsons and Peter J.H. Jones School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada and School of Physical and Health Education, Queen’s University, Kingston, Ontario, Canada.
http://www.obesityresearch.org/cgi/content/abstract/11/3/395?ijkey=3
7db2c65fd9ddea6e2bf7238a553036f04186f96&keytype2=tf_ipsecsha

535

Medium-Chain Oil Reduces Fat Mass and Down-regulates Expression of Adipogenic Genes in Rats - Jianrong Han, James A. Hamilton, James L. Kirkland, Barbara E. Corkey and Wen Guo Dept. of Medicine, 650 Albany St., Boston, MA.

536

Medium-Chain Triglycerides Increase Energy Expenditure and Decrease Adiposity in Overweight Men (See 534 above).
http://www.obesityresearch.org/cgi/content/abstract/11/6/734

537

Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure - American Jnl. of Clinical Nutrition, Vol. 82, No. 2, 320 – 326, August 2005 - C Lawrence Kien, Janice Y Bunn and Figen Ugrasbul - Dept. of Pediatrics, University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX, and the Dept. of Medical Biostatistics, University of Vermont, USA.
http://www.ajcn.org/cgi/content/abstract/82/2/320

538

Plasma palmitoleic acid content and obesity in children. - Am J Clin Nutr. 2005 Oct;82(4):747 –50. Okada T, Furuhashi N, Kuromori Y, Miyashita M, Iwata F, Harada K. - Dept. of Pediatrics, Nihon University School of Medicine, Tokyo, Japan. Jianrong Han, James A. Hamilton, James L. Kirkland, Barbara E. Corkey and Wen Guo, - Dept. of Medicine, Room 805, 650 Albany St., Boston, MA PubMed 16210702.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16210702

539

Modifications induced by dietary lipid source in adipose tissue phospholipid fatty acids and their consequences in lipid mobilization - Brtiish Jnl. of Nutrition82: 319 – 327 Maria P. - Portillo, Ana I. Tueros, Javier S. Perona, Valentina Ruiz-Guti?rrez, Isabel Torres and M. Teresa Macarulla1- Dept. of Nutrition and Food Science University of Pais Vasco, Spain Instituto de la Grasa (C.S.I.C.), Sevilla, Spain.
http://journals.cambridge.org/action/displayFulltext?type=6&fid=885212&jid=&volumeId=
&issueId=04&aid=885208&fulltextType=RA&fileId=S000711459900152X

540

Production of eicosapentaenoic and docosahexaenoic acid-containing oils in transgenic land plants for human and aquaculture nutrition see 2 above.

541

Fish Farming May Soon Overtake Cattle Ranching As a Food Source Lester R. Brown.
http://www.eart-olicy.org/Alerts/Alert9.htm

542

Lipid composition and contaminants in farmed and wild salmon. - Environ. Sci. Technol., 39 (22), 8622  – 8629, 2005 - M. Coreen Hamilton, Ronald A. Hites, Steven J. Schwager, Jeffery A. Foran Barbara A. Knuth and David O. Carpenter - AXYS Analytical Services, Sidney, British Columbia, Canada, School of Public and Environmental Affairs, Indiana University, Dept. of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York Midwest Center for Environmental Science and Public Policy, Milwaukee, Wisconsin Dept. of Natural Resources, Cornell University, Ithaca, New York and Institute for Health and the Environment, University at Albany, New York.
http://pubs.acs.org/cg-in/abstract.cgi/esthag/2005/39/i22/abs/es050898y.html

543

INTENSIVE MARINE FISH AQUACULTURE WWF.
http://www.panda.org/about_wwf/what_we_do/marine/problems/aquaculture/index.cfm

544

Antarctic Krill: a case study on the ecosystem implications of fishing Lighthouse Foundation By Virginia Gascón & Rodolfo Werner.
http://www.lighthous-oundation.org/fileadmin/LHF/PDF/Antarcti-ril-F_EN.pdf

545

Net loss of wild fish to produce farmed salmon.

546

Fish Farming May Soon Overtake Cattle Ranching As a Food Source - Lester R. - October 3, 2000 – 92001 Earth Policy Institute Brown.
http://www.eart-olicy.org/Alerts/Alert9.htm

547

AG OPPORTUNITIES *Small Farms *New Family Farms *Agricultural Alternatives Vol. 8, No. 2 Sept – Oct 1997.
http://agebb.missouri.edu/mac/agopp/arc/agopp015.txt

548

http://www.nutritiondata.com/facts – B00001 – 01c2134.html

549

Antarctic Krill: a case study on the ecosystem implications of fishing See 544.

550

Where to find omega – 3 fatty acids and how feeding animals with diet enriched in omega – 3 fatty acids to increase nutritional value of derived products for human: what is actually useful? - J Nutr Health Aging. 2005 Jul – Aug;9(4):232 – 42 - Bourre JM. - INSERM Neuro-pharmaco-nutrition, Hopital Fernand Widal, Paris. Pubmed 15980924.
http://cat.inist.fr/?aModele=afficheN&cpsidt=17101184

551

Comparing the Fatty Acid Composition of Organic and Conventional Milk - J. Dairy Sci. 89:1938 – 1950K. A. Ellis, G. Innocent, D. Grove-White, P. Cripps, W. G. McLean, C. V. Howard and M. Mihm - University of Glasgow Veterinary School University of Liverpool, Faculty of Veterinary Medicine Dept. of Pharmacology & Therapeutics School of Biomedical Sciences, Liverpool, Molecular Biosciences, University of Ulster University of Glasgow Veterinary School.
http://www.dair-cience.org/cgi/content/abstract/89/6/1938

552

High omega 3 Fatty Acid Content in Alpine Cheese The Basis for an Alpine Paradox - American Heart Association, Inc 2004;109:103 – 107 - Christa B. Hauswirth, MD; Martin R.L. Scheeder, Dr sg agr; Jürg H. Beer, MD - Dept. of Medicine, Kantonsspital Baden, and the Federal Institute of Technology, Zürich, Switzerland.
http://circ.ahajournals.org/cgi/content/abstract/109/1/103

553

Flax: New Uses and Demands Berglund, D.R. p. 358–360. In: J. Janick and A. Whipkey.
http://www.hort.purdue.edu/newcrop/ncnu02/v-58.html

554

An integrated production system of highly purified eicosapentaenoic acid from microalgae. improvement of photobioreactors and downstream processing. - Cordis.
http://cordis.europa.eu/data/PROJ_BRITE/ACTIONeqDndSESSIONeq
14611200595ndDOCeq51ndTBLeqEN_PROJ.htm

555

1. Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish - Transgenic Res. 2005 Apr;14(2):159 – 65 - Alimuddin, Yoshizaki G, Kiron V, Satoh S, Takeuchi T. - Dept. of Marine Biosciences, Tokyo University of Marine Science and Technology, Japan. PubMed 16022387.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16022387

556

June 2006 ISB News Report Yifan Dai and Randall S. Prather
http://www.isb.vt.edu/news/2006/news06.jun.htm.

557

Production of eicosapentaenoic and docosahexaenoic acid-containing oils in transgenic land plants for human and aquaculture nutrition. See 2 above.

558

Sleep and metabolic control: Waking to a problem? Clinical and Experimental Pharmacology and Physiology, Volume 34, Numbers 1 – 2, January 2007 , pp. 1 – 9 - Michael I Trenell, Sleep and Circadian Research Group, Woolcock Institute of Medical Research and , Nathaniel S Marshall Sleep and Circadian Research Group, Woolcock Institute of Medical Research and Central Clinical School, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia and Naomi L Rogers Sleep and Circadian Research Group, Woolcock Institute of Medical Research and Central Clinical School, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia. Sleep and Circadian Research Group, Woolcock Institute of Medical Research and Central Clinical School, Faculty of Medicine, University of Sydney, Australia.
http://www.ingentaconnect.com/content/bsc/cep/2007/00000034/F0020001/art00001

559

Melatonin (with the help of Wikipedia)
http://en.wikipedia.org/wiki/Melatonin .

560

Permeability of pure lipid bilayers to melatonin - J Pineal Res. 1995 Oct;19(3):123 – 6. - Costa EJ, Lopes RH, Lamy-Freund MT - Instituto de Física, Universidade de São Paulo, Brazil. PubMed 8750345.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=8750345

561

Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction. - Life Sci. 2001 May 11;68(25):2835 – 44 - Sauer LA, Dauchy RT, Blask DE. - Laboratory of Experimental Neuroendocrinology/Oncology, Bassett Research Institute, Cooperstown, NY 13326 – 1394, USA. PubMed 11432449.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=11432449

562

Effect of an n – 3 fatty acid-deficient diet on the adenosine-dependent melatonin release in cultured rat pineal. - J Neurochem. 1993 Sep;61(3):1057 – 63 Gazzah N, Gharib A, Delton I, Moliere P, Durand G, Christon R, Lagarde M, Sarda N. - INSERM U. 352, Laboratoire de Chimie Biologique, INSAL, Villeurbanne, France. PubMed 8360673.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=8360673

563

N – 3 fatty acid deficiency in the rat pineal gland: effects on phospholipid molecular species composition and endogenous levels of melatonin and lipoxygenase products. - J Lipid Res. 1998 Jul;39(7):1397 – 403. Zhang H, Hamilton H, Salem N Jr, Kim HY. - Section of Mass Spectrometry, National Institute on Alcohol Abuse and Alcoholism. PubMed 9684742.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=9684742

564

Dietary Docosahexaenoic Acid-Enriched Phospholipids Normalize Urinary Melatonin Excretion in Adult (n – 3) Polyunsaturated Fatty Acid-Deficient Rats - Jnl. of Nutrition. 1999;129:2074 – 2080. - Monia Zaouali-Ajina, Abdallah Gharib, Georges Durand, Noureddine Gazzah, Bruno Claustrat, Claude Gharib and Nicole Sarda - Laboratoire de Physiologie de l’Environnement, Faculté de Médecine Lyon Grange-Blanche, Laboratoire de Neuropharmacologie Moléculaire UFR Laënnec,Lyon INRA Laboratoire de Nutrition et Sécurité Alimentaire, Jouy en Josas, Laboratoire de Radiopharmacie Radioanalyse, Hôpital Neuro-Cardiologique, Lyon, France, Ecole des Cadres et Techniciens de la Santé, Monastir.
http://jn.nutrition.org/cgi/content/full/129/11/2074

565

Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity. - J Pineal Res. 2002 Jan;32(1):26 – 33 - Nishida S, Segawa T, Murai I, Nakagawa S. - Dept. of Biochemistry, Dept. of the Third Internal Medicine, Nihon University School of Medicine, Itabashi, Tokyo, Japan. PubMed 11841597.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=11841597

566

Effect of pinealectomy on plasma levels of insulin and leptin and on hepatic lipids in type 2 diabetic rats. - J Pineal Res. 2003 Nov;35(4):251 – 6 - Nishida S, Sato R, Murai I, Nakagawa S. Dept. of Biochemistry, Nihon University School of Medicine, Japan. PubMed 14521630.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=14521630

567

Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine and N1-acetyl-5-methoxykynuramine, in macrophages. - J Neuroimmunol. 2005 Aug;165(1 – 2):139 – 49 - Mayo JC, Sainz RM, Tan DX, Hardeland R, Leon J, Rodriguez C, Reiter RJ. - Dept. de Morfología y Biología Celular, Universidad de Oviedo, Asturias, España PubMed 15975667.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=15975667

568

Melatonin: an endogenous negative modulator of 12-lipoxygenation in the rat pineal gland - Biochem. J. (1999) 344, 487–493 - Hongjian ZHANG , Mohammed AKBAR and Hee-Yong Kim - Section of Mass Spectrometry, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, 12501 Washington Avenue, Rockville, MD 20852, U.S.A.
http://66.102.9.104/search?q=cache:AR3lP6EV5U0J:www.biochemj.org/bj/344/0487/3440487.
pdf+melatonin+dha&hl=en&ct=clnk&cd=7&gl=uk&client=firefo-

569

Melatonin as a Pharmacological Agent against Neuronal Loss in Experimental Models of Huntington’s Disease, Alzheimer’s Disease and Parkinsonism - Annals of the New York Academy of Sciences 890:471 – 485 (1999) - Russel J. Reiter, Javier Cabrera, Rosma M. Sainz, Juan Carlos Mayo Lucien C. Manchester and Dun-Xian Tan - Dept. of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio Texas.
http://www.annalsnyas.org/cgi/content/abstract/890/1/471

570

Melatonin and its kynurenin-like oxidation products affect the microbicidal activity of neutrophils. - Silva SO, Carvalho SR, Ximenes VF, Okada SS, Campa A. Departamento de Análises Clínicas e Toxicológicas, - Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, CEP 05508-900, São Paulo, SP, Brazil. - PubMed 16242372.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16242372

571

Melatonin and its kynurenin-like oxidation products affect the microbicidal activity of neutrophils. - Microbes Infect. 2006 Feb;8(2):420 – 5 Silva SO, Carvalho SR, Ximenes VF, Okada SS, Campa A. - Dept. de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, CEP 05508 – 900, São Paulo, SP, Brazil. PubMed 16242372.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16242372

572

Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity. - Cos S, Gonzalez A, Guezmes A, Mediavilla MD, Martinez-Campa C, Alonso-Gonzalez C, Sanchez-Barcelo EJ. - Dept. of Physiology and Pharmacology, School of Medicine, University of Cantabria, Santander, Spain Pathological Anatomy Service, Sierrallana Hospital, Torrelavega, Cantabria, Spain.
http://www.ncbi.nlm.nih.gov/entrez/...t_uids=16080194

573

Melatonin modulates aromatase activity in MCF – 7 human breast cancer cells - Int J Cancer. 2006 Jan 15;118(2):274 – 8 - Cos S, Martinez-Campa C, Mediavilla MD, Sanchez-Barcelo EJ. -Dept. of Physiology and Pharmacology, School of Medicine, University of Cantabria, Santander, Spain. PubMed 156834691:
http://www.ncbi.nlm.nih.gov/entrez/...uids=156834691:

574

Estrogen-signaling pathway: a link between breast cancer and melatonin oncostatic actions. - Cancer Detect Prev. 2006;30(2):118 – 28 - Cos S, Gonzalez A, Martinez-Campa C, Mediavilla MD, Alonso-Gonzalez C, Sanchez-Barcelo EJ. - Dept. of Physiology and Pharmacology, School of Medicine, University of Cantabria, 39011 Santander, Spain. PubMed 16647824.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16647824

575

Melatonin-estrogen interactions in breast cancer. - J Pineal Res. 2005 May;38(4):217 – 22 - Sanchez-Barcelo EJ, Cos S, Mediavilla D, Martinez-Campa C, Gonzalez A, Alonso-Gonzalez C. - Dept. of Physiology and Pharmacology, School of Medicine, University of Cantabria, Spain. PubMed 15813897.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=15813897

576

Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study. - Persson,-C; Glimelius,-B; Ronnelid,-J; Nygren,-P. Department of Oncology, Radiology and Clinical Immunology, University Hospital, Uppsala University, Uppsala, Sweden PubMed 15723745
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=15723745

577

Melatonin Attenuates Estradiol-Induced Oxidative Damage to DNA: Relevance for Cancer Prevention - Experimental Biology and Medicine 226:707 – 712 (2001) - Malgorzata Karbownik, Russel J. Reiter, Susanne Burkhardt, Eloisa Gitto, Dun-Xian Tan and Andrzej Lewiñski - Dept. of Cellular and Structural Biology, University of Texas Health Science Center, Texas; Dept. of Thyroidology, Institute of Endocrinology, Medical University of Lódz, 5 Poland.
http://www.ebmonline.org/cgi/content/full/226/7/707

578


http://en.wikipedia.org/wiki/Pineal_gland

579

Infants to Adolescents: Research Update, vol. 1 no. 6 Brain Watching Beverly J. Roder, Ph.D. and Mabel L. Sgan, Ph.D.
http://www.loni.ucla.edu/~thompson/MEDIA/itoa.html

580

J Pineal Res. 2005 Sep;39(2):164 – 9. Protective effect of melatonin on ascorbate-Fe2+ lipid peroxidation of polyunsaturated fatty acids in rat liver, kidney and brain microsomes: a chemiluminescence study. - Leaden PJ, Catalá A. - Cátedra de Bioquímica, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Argentina. PubMed 16098094.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16098094

581

A maternal diet high in n6 polyunsaturated fats alters mammary gland development. . . See210 above.

582

Early sexual maturation, central adiposity and subsequent overweight in late adolescence. A four-year follow-up of 1605 adolescent Norwegian boys and girls: the Young HUNT study - BMC Public Health. 2007; 7: 54. - Grete H Bratberg,Tom IL Nilsen,Turid L Holmen,and Lars J Vatten - HUNT Research Centre, Norwegian University of Science and Technology, Verdal, Dept. of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Nord-Trøndelag University College, Levanger, Norway. PubMed 1855319.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&rendertype=abstract&artid=1855319

583

Nutritional and developmental regulation of plasma leptin in dairy cattle. - J Dairy Sci. 2003 Oct;86(10):3206 – 14. - Block SS, Smith JM, Ehrhardt RA, Diaz MC, Rhoads RP, Van Amburgh ME, Boisclair YR. Dept. of Animal Science, Cornell University NY. USA. PubMed 14594240.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=14594240

584

Age impairments in sleep, metabolic and immune functions. - Exp Gerontol. 2004 Nov – Dec;39(11 – 12):1739 – 43 - Prinz PN. - Dept. of Biobehavioral Nursing and Health Systems, University of Washington, Box 357 – 266, Seattle, WA 98195, USA. PubMed 15582290.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=15582290

585

Effect of pinealectomy on plasma levels of insulin and leptin and on hepatic lipids in type 2 diabetic rats. - J Pineal Res. 2003 Nov;35(4):251 – 6 - Nishida S, Sato R, Murai I, Nakagawa S. - Dept. of Biochemistry, Nihon University School of Medicine, Tokyo, Japan PubMed 14521630.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=14521630

586

Effect of exogenous melatonin on sexual behaviours in West African Dwarf goat - J O Daramola, A A Adeloye and A O Soladoye - Dept. of Animal Production, Nigeria Dept. of Human Physiology, University of Ilorin, Nigeria.
http://cipav.org.co/lrrd/lrrd18/9/dara18133.htm

587

Title: Effect of melatonin on photoperiod responses, ovarian secretion of oestrogen, and coital responses in the domestic cat. - Leyva, H : Madley, T : Stabenfeldt, G H - J-Reprod-Fertil-Suppl. 1989; 39135 – 42.
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=272838

588

Effects of melatonin on progesterone production by human granulosa lutein cells in culture.- Fertil Steril. 1992 Sep;58(3):526 – 9. Brzezinski A, Fibich T, Cohen M, Schenker JG, Laufer N. - Dept. of Obstetrics and Gynecology, Hadassah Medical Center, Jerusalem, Israel. PubMed 1521647.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=1521647&dopt=Abstract

589

Development of the Cerebral Cortex:XV. Sexual Differentiation of the Central Nervous System - J Am Acad Child Adolesc Psychiatry, 37(12): 1337 – 1339, 1998 - Roger A. Gorski, Ph.D.
http://www.med.yale.edu/chldstdy/plomdevelop/development/March99.html

590

Testostrone and aggressiveness - Marco Giammanco, Garden Tabacchi, Santo Giammanco, Danila Di Majo and Maurizio La Guardia - Endocrinology (2005).
http://www.medscimonit.com/pub/vol_11/no_4/4259.pdf

591

Omega – 3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention - Int Rev Psychiatry. 2006 Apr;18(2):107 – 18. - Hibbeln JR, Ferguson TA, Blasbalg TL. National Institute on Alcohol Abuse and Alcoholism, Bethesda,USA. PubMed 16777665.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16777665

592

Relationships Between Types of Fat Consumed and Serum Estrogen and Androgen Concentrations in Japanese Men - Nutrition and Cancer 2000, Vol. 38, No. 2, Pages 163 – 167 - Chisato Nagata, Naoyoshi Takatsuka, Norito Kawakami, Hiroyuki Shimizu.
http://www.leaonline.com/doi/abs/10.1207/S15327914NC382_4

593

Region-Specific Regulation of Cytochrome P450 Aromatase Messenger Ribonucleic Acid by Androgen in Brains of Male Rhesus Monkeys - Biology of Reproduction 62, 1818 – 1822 (2000) - J.A. Resko A.C. Pereyra-Martinez, H.L. Stadelman, and C.E. Roselli - Dept. of Physiology and Pharmacology, School of Medicine, Oregon Health Sciences University, Oregon.
http://www.biolreprod.org/cgi/content/full/62/6/1818

594

Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects - Giltay Erik J. Gooren Louis J. G. Toorians Arno W. F. T. Katan Martijn B. Zock Peter L. - Psychiatric Center GGZ Delfland, Delft, Dept. of Endocrinology, Andrology Unit, VU University Medical Center, Amsterdam, Wageningen Center for Food Sciences, Wageningen University.
http://cat.inist.fr/?aModele=afficheN&cpsidt=16253504

595

Docosahexaenoic acid concentrations are higher in women than ….See 594 Above.

596

Free Fatty Acids Increase Androgen Precursors in Vivo - The Jnl. of Clinical Endocrinology & Metabolism Vol. 91, No. 4 1501 – 1507 - K. Mai, T. Bobbert, V. Kullmann, J. Andres, H. Rochlitz, M. Osterhoff, M. O. Weickert, V. Bähr, M. Möhlig, A. F. H. Pfeiffer, S. Diederich and J. Spranger Dept. of Endocrinology, Diabetes and Nutrition Charite–University Medicine Berlin, Campus Benjamin Franklin, Berlin, Dept. of Clinical Nutrition German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany; and Endokrinologikum (S.D.), 10117 Berlin, Germany.
http://jcem.endojournals.org/cgi/content/full/91/4/1501

597

Inhibition of gonadotropin-stimulated ovarian steroid production …See 309 above.

598

Free fatty acids increase androgen precursors in vivo. - J Clin Endocrinol Metab. 2006 Apr;91(4):1501 – 7 Mai K, Bobbert T, Kullmann V, Andres J, Rochlitz H, Osterhoff M, Weickert MO, Bahr V, Mohlig M, Pfeiffer AF, Diederich S, Spranger J. - Dept. of Endocrinology, Diabetes and Nutrition, Charite-University Medicine Berlin. PubMed 16434463.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16434463

599

Prostaglandin receptors are mediators of vascular function in endometrial pathologies. - Mol Cell Endocrinol. 2006 Jun 27;252(1 – 2):191 – 200. - Jabbour HN, Sales KJ, Smith OP, Battersby S, Boddy SC. - MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen’s Medical Research Institute, Edinburgh. PubMed 16701939.
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=16701939

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VEGETABLE OILS ARE OFTEN HIGH IN OMEGA 6

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